Abstract: Fusion multidisciplinary subjects in order to present a unique and complementary perspective may enhance and extend the knowledge acquisition, and consequently, the student experience. In this paper we report a case study on methodology, which interlinks various subjects creating and engaging learning process by combining Science, Technology, Engineering and Mathematics (STEM) and Design. In line with this, an Experimental Interaction Design summer course was designed and implemented based on a multi-cultural, defiant and creative environment in order to provide an effective learning on solving the real-world challenges. Twelve students were involved in this initiative, which resulted in the development of several projects such as a pets’ tracking and behavior analysis, a smart home for elderlies, and a medication reminder device, in which design, prototyping, usability evaluation and programming concepts were combined. In this report, we focus on the study design with the aim to provide scaffolding for multidisciplinary teams of students in design-based projects that require STEM competences.