{"id":1105,"date":"2026-04-25T09:04:00","date_gmt":"2026-04-25T08:04:00","guid":{"rendered":"https:\/\/igormatias.com\/?p=1105"},"modified":"2026-04-28T09:04:55","modified_gmt":"2026-04-28T08:04:55","slug":"passive-digital-health-technologies-for-alzheimers-disease-screening-and-diagnosis-a-systematic-review","status":"publish","type":"post","link":"https:\/\/igormatias.com\/pt\/2026\/04\/25\/passive-digital-health-technologies-for-alzheimers-disease-screening-and-diagnosis-a-systematic-review\/","title":{"rendered":"Passive digital health technologies for Alzheimer\u2019s disease screening and diagnosis: a systematic review"},"content":{"rendered":"<p><span class=\"LabelSearchRepeater\">Abstract: Passive digital health technologies (DHTs) are increasingly promoted as scalable tools for detecting Alzheimer\u2019s disease and related dementias (ADRD) earlier than routine clinic visits. We searched six major databases for English-language studies published between January 2014 and July 2024 that used passively collected, real-world DHT data for ADRD screening or diagnosis. Thirty studies met the criteria. Population sizes were highly skewed (median = 87; range 12-82,829), and most designs were longitudinal (53%) and fully passive (68%). Wrist-worn accelerometers and photoplethysmography sensors dominated, though several studies also used gait, sleep, voice, radar, or posture-tracking devices. A cross-study synthesis showed that those two modalities were primarily applied to memory, attention, and language tasks. Nineteen studies reported median accuracy, sensitivity, specificity, and precision between 80-90%, with F1-score and AUC medians approaching 78%, though relying on in-sample cross-validation rather than external cohorts. Reference standards varied widely, data-quality criteria were seldom reported, and fewer than 5% shared datasets publicly. Classification was the predominant modeling strategy, with regression emerging only in recent years. Overall, passive DHTs show promise as low-burden triage tools for population-level ADRD screening, but routine deployment will require more diverse cohorts, harmonized reporting, multimodal privacy-preserving analytics, and rigorous human-factors evaluation.<\/span><\/p>\n<p>Igor Matias<sup>1,2<\/sup>, Pawe\u0142 Proci\u00f3w<sup>3<\/sup>, Eric J. Daza<sup>4,5<\/sup>, Matthias Kliegel<sup>2<\/sup>, Katarzyna Wac<sup>1<\/sup><\/p>\n<p><sup>1<\/sup>Quality of Life Technologies Lab, UNIGE, Switzerland, <sup>2<\/sup>Cognitive Aging Lab, UNIGE, Switzerland, <sup>3<\/sup>DSW University of Lower Silesia, Wroc\u0142aw, Poland, <sup>4<\/sup>Stats-of-1, USA, <sup>5<\/sup>Boehringer Ingelheim Pharmaceuticals Inc., USA<\/p>\n<p><span id=\"ContentPlaceHolder1_LinkPaperPage_LinkPaperContent_AuxInProceeding\" class=\"PublicationsDetailNormal\">In npj Digital Medicine, 25 April 2026.<\/span><\/p>\n<p>Article: <a href=\"https:\/\/doi.org\/10.1038\/s41746-026-02650-1\">here<\/a><\/p>\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Abstract: Passive digital health technologies (DHTs) are increasingly promoted as scalable tools for detecting Alzheimer\u2019s disease and related dementias (ADRD) earlier than routine clinic visits. We searched six major databases for English-language studies published between January 2014 and July 2024 that used passively collected, real-world DHT data for ADRD screening or diagnosis. Thirty studies met the criteria. Population sizes were highly skewed (median = 87; range 12-82,829), and most designs were longitudinal (53%) and fully passive (68%). Wrist-worn accelerometers and photoplethysmography sensors dominated, though several studies also used gait, sleep, voice, radar, or posture-tracking devices. A cross-study synthesis showed that those two modalities were primarily applied to memory, attention, and language tasks. Nineteen studies reported median accuracy, sensitivity, specificity, and precision between 80-90%, with F1-score and AUC medians approaching 78%, though relying on in-sample cross-validation rather than external cohorts. Reference standards varied widely, data-quality criteria were seldom reported, and fewer than 5% shared datasets publicly. Classification was the predominant modeling strategy, with regression emerging only in recent years. Overall, passive DHTs show promise as low-burden triage tools for population-level ADRD screening, but routine deployment will require more diverse cohorts, harmonized reporting, multimodal privacy-preserving analytics, and rigorous human-factors evaluation.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[12],"tags":[],"class_list":["post-1105","post","type-post","status-publish","format-standard","hentry","category-journal"],"gutentor_comment":0,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Passive digital health technologies for Alzheimer\u2019s disease screening and diagnosis: a systematic review<\/title>\n<meta name=\"description\" content=\"Abstract: Passive digital health technologies (DHTs) are increasingly promoted 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