{"id":713,"date":"2022-08-25T08:32:56","date_gmt":"2022-08-25T07:32:56","guid":{"rendered":"https:\/\/igormatias.com\/?p=713"},"modified":"2026-02-02T13:07:03","modified_gmt":"2026-02-02T13:07:03","slug":"what-possibly-affects-nighttime-heart-rate-conclusions-from-n-of-1-observational-datawhat-possibly-affects-nighttime-heart-rate-conclusions-from-n-of-1-observational-data","status":"publish","type":"post","link":"https:\/\/igormatias.com\/pt\/2022\/08\/25\/what-possibly-affects-nighttime-heart-rate-conclusions-from-n-of-1-observational-datawhat-possibly-affects-nighttime-heart-rate-conclusions-from-n-of-1-observational-data\/","title":{"rendered":"What possibly affects nighttime heart rate? Conclusions from N-of-1 observational data"},"content":{"rendered":"<p><span class=\"LabelSearchRepeater\">Abstract: <\/span><i>Heart rate<\/i> (HR), especially at nighttime, is an important biomarker for cardiovascular health. It is known to be influenced by overall physical fitness, as well as daily life physical or psychological stressors like exercise, insufficient sleep, excess alcohol, certain foods, socialization, or air travel causing physiological arousal of the body. However, the exact mechanisms by which these stressors affect nighttime HR are unclear and may be highly idiographic (i.e. individual-specific). A single-case or \u201c<i>n-of-1\u201d observational study<\/i> (N1OS) is useful in exploring such suggested effects by examining each subject&#8217;s exposure to both stressors and baseline conditions, thereby characterizing suggested effects specific to that individual. Our objective was to test and generate individual-specific N1OS hypotheses of the suggested effects of daily life stressors on nighttime HR. As an N1OS, this study provides conclusions for each participant, thus not requiring a representative population. We studied three healthy, nonathlete individuals, collecting the data for up to four years. Additionally, we evaluated <i>model-twin randomization<\/i> (MoTR), a novel Monte Carlo method facilitating the discovery of personalized interventions on stressors in daily life. We found that physical activity can increase the nighttime heart rate amplitude, whereas there were no strong conclusions about its suggested effect on total sleep time. Self-reported states such as exercise, yoga, and stress were associated with increased (for the first two) and decreased (last one) average nighttime heart rate. This study implemented the MoTR method evaluating the suggested effects of daily stressors on nighttime heart rate, sleep time, and physical activity in an individualized way: via the N-of-1 approach. A Python implementation of MoTR is freely available.<\/p>\n<div class=\"NLM_sec NLM_sec_level_1\">\n<p>Igor Matias, Eric J. Daza, Katarzyna Wac<\/p>\n<\/div>\n<p><span id=\"ContentPlaceHolder1_LinkPaperPage_LinkPaperContent_AuxInProceeding\" class=\"PublicationsDetailNormal\">In SAGE Digital Health, 2022.<\/span><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1177%2F20552076221120725\" target=\"_blank\" rel=\"noopener noreferrer\">https:\/\/doi.org\/10.1016\/j.cosrev.2020.100334<\/a><\/p>\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Abstract:<br \/>\nBackground<br \/>\nHeart rate (HR), especially at nighttime, is an important biomarker for cardiovascular health. It is known to be influenced by overall physical fitness, as well as daily life physical or psychological stressors like exercise, insufficient sleep, excess alcohol, certain foods, socialization, or air travel causing physiological arousal of the body. However, the exact mechanisms by which these stressors affect nighttime HR are unclear and may be highly idiographic (i.e. individual-specific). A single-case or \u201cn-of-1\u201d observational study (N1OS) is useful in exploring such suggested effects by examining each subject&#8217;s exposure to both stressors and baseline conditions, thereby characterizing suggested effects specific to that individual.<br \/>\nObjective<br \/>\nOur objective was to test and generate individual-specific N1OS hypotheses of the suggested effects of daily life stressors on nighttime HR. As an N1OS, this study provides conclusions for each participant, thus not requiring a representative population.<br \/>\nMethods<br \/>\nWe studied three healthy, nonathlete individuals, collecting the data for up to four years. Additionally, we evaluated model-twin randomization (MoTR), a novel Monte Carlo method facilitating the discovery of personalized interventions on stressors in daily life.<br \/>\nResults<br \/>\nWe found that physical activity can increase the nighttime heart rate amplitude, whereas there were no strong conclusions about its suggested effect on total sleep time. Self-reported states such as exercise, yoga, and stress were associated with increased (for the first two) and decreased (last one) average nighttime heart rate.<br \/>\nConclusions<br \/>\nThis study implemented the MoTR method evaluating the suggested effects of daily stressors on nighttime heart rate, sleep time, and physical activity in an individualized way: via the N-of-1 approach. A Python implementation of MoTR is freely available.<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":"","_links_to":"","_links_to_target":""},"categories":[12],"tags":[],"class_list":["post-713","post","type-post","status-publish","format-standard","hentry","category-journal"],"gutentor_comment":0,"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.1 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>What possibly affects nighttime heart rate? 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